Osteosarcoma is the Garden most common primary malignant bone tumor with a high risk of metastasis and recurrence.Metabolic reprogramming is a hallmark of osteosarcoma and other cancers and is associated with genetic and epigenetic alterations.RUNX2 is an important transcription factor for osteoblastic differentiation, and aberrant expression of th
Abstract Autophagy is a widespread physiological process in the body, which also protects the host by degrading invading pathogens and harmful substances during pathological conditions.Nevertheless, Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, has evolved strategies to subvert autophagy by modulating microRNA (miRNA) expre
One of the most challenging tasks in clinical trials is finding the maximum tolerated dose (MTD) to be tested in the next phase.An assurance for the safety of the patients and recommendation of a suitable dose for phase II are the main objectives of a phase I trial.The MTD can be identified through various Nail Buffer approaches.A non-parametric ap